Specificity and Completion Time Distributions of Biochemical Processes

摘要: In order to produce specific complex structures from a large set of similar biochemical building blocks, many systems require high sensitivity small molecular differences. The first and most common model used explain this specificity is kinetic proofreading, which has been extended variety detection DNA mismatch cell signaling processes. While the specification properties proofreading are well known were studied in various contexts, very little about its temporal behavior. work, we study dynamical discrete stochastic two branch schemes. Using Laplace transform corresponding chemical master equation, obtain an analytical solution for completion time distribution. particular provide expressions mean variance process times. We also show that, wide range parameters distinguishing between different products can be reduced much simpler three point process. Our results allow systematic interplay times as testing validity biological systems.