Prognostic Significance of MicroRNAs in Glioma: A Systematic Review and Meta-Analysis.
作者： Yanming Zhang , Jigang Chen , Qiang Xue , Junyu Wang , Liang Zhao
DOI: 10.1155/2019/4015969
关键词:
摘要: Purpose. Different microRNAs (miRs) have been demonstrated to relate with the outcome of glioma patients, while conclusions are inconsistent. We perform a meta-analysis clarify relationship between different miRs and prognosis glioma. Methods. Related studies were retrieved from PubMed, Embase, Cochrane Library. Pooled hazard ratios (HRs) expression for survival 95% confidence intervals (CIs) calculated using random-effects model. Results. A total 15 4708 patients ultimately included. Increased miR-15b (HR, 1.584; CI, 1.199-2.092), 21 1.591; 1.278-1.981), 148a 1.122; 1.023-1.231), 196 1.877; 1.033-3.411), 210 1.251; 1.010-1.550), 221 1.269; 1.054-1.527) or decreased miR-106a 0.809; 0.655-0.998) 124 0.833; 0.729-0.952) was correlated poor patients. Conclusions. miR-15b, 21, 148a, 196, 210, 221, 106a, valuable biomarkers which might be used in clinical settings.
hindawi.com参考文章(97)
Lei Han, Xiao Yue, Xuan Zhou, Feng‐Ming Lan, Gan You, Wei Zhang, Kai‐Liang Zhang, Chun‐Zhi Zhang, Jin‐Quan Cheng, Shi‐Zhu Yu, Pei‐Yu Pu, Tao Jiang, Chun‐Sheng Kang, MicroRNA-21 expression is regulated by β-catenin/STAT3 pathway and promotes glioma cell invasion by direct targeting RECK. CNS Neuroscience & Therapeutics. ,vol. 18, pp. 573- 583 ,(2012) , 10.1111/J.1755-5949.2012.00344.X
Z Wang, B Wang, Y Shi, C Xu, H L Xiao, L N Ma, S L Xu, L Yang, Q L Wang, W Q Dang, W Cui, S C Yu, Y F Ping, Y H Cui, H F Kung, C Qian, X Zhang, X W Bian, Oncogenic miR-20a and miR-106a Enhance the Invasiveness of Human Glioma Stem Cells by Directly Targeting TIMP-2 Oncogene. ,vol. 34, pp. 1407- 1419 ,(2015) , 10.1038/ONC.2014.75
Julia Winter, Stephanie Jung, Sarina Keller, Richard I. Gregory, Sven Diederichs, Many roads to maturity: microRNA biogenesis pathways and their regulation. Nature Cell Biology. ,vol. 11, pp. 228- 234 ,(2009) , 10.1038/NCB0309-228
Lin Wu, Gang Li, Dayun Feng, Huaizhou Qin, Li Gong, Jian Zhang, Zhiguo Zhang, MicroRNA-21 expression is associated with overall survival in patients with glioma Diagnostic Pathology. ,vol. 8, pp. 200- 200 ,(2013) , 10.1186/1746-1596-8-200
Rui Zhang, Bo Pang, Tao Xin, Hua Guo, Yi Xing, Shangchen Xu, Bin Feng, Bin Liu, Qi Pang, Plasma miR-221/222 Family as Novel Descriptive and Prognostic Biomarkers for Glioma Molecular Neurobiology. ,vol. 53, pp. 1452- 1460 ,(2016) , 10.1007/S12035-014-9079-9
Heiko Hermeking, MicroRNAs in the p53 network: micromanagement of tumour suppression. Nature Reviews Cancer. ,vol. 12, pp. 613- 626 ,(2012) , 10.1038/NRC3318
Takashi Sasayama, Masamitsu Nishihara, Takeshi Kondoh, Kohkichi Hosoda, Eiji Kohmura, MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC. International Journal of Cancer. ,vol. 125, pp. 1407- 1413 ,(2009) , 10.1002/IJC.24522
Min Ling, Yuan Li, Yuan Xu, Ying Pang, Lu Shen, Rongrong Jiang, Yue Zhao, Xiaojun Yang, Jianping Zhang, Jianwei Zhou, Xinru Wang, Qizhan Liu, None, Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation. Free Radical Biology and Medicine. ,vol. 52, pp. 1508- 1518 ,(2012) , 10.1016/J.FREERADBIOMED.2012.02.020
Donna F Stroup, Jesse A Berlin, Sally C Morton, Ingram Olkin, G David Williamson, Drummond Rennie, David Moher, Betsy J Becker, Theresa Ann Sipe, Stephen B Thacker, Meta-analysis of Observational Studies in EpidemiologyA Proposal for Reporting JAMA. ,vol. 283, pp. 2008- 2012 ,(2000) , 10.1001/JAMA.283.15.2008
Liguang Wang, Jianyu Yu, Jun Xu, Chunlong Zheng, Xiaowei Li, Jiajun Du, The analysis of microRNA-34 family expression in human cancer studies comparing cancer tissues with corresponding pericarcinous tissues. Gene. ,vol. 554, pp. 1- 8 ,(2015) , 10.1016/J.GENE.2014.10.032