Polyelectrolyte complexes between (cross-linked) N-carboxyethylchitosan and (quaternized) poly[2-(dimethylamino)ethyl methacrylate]: preparation, characterization, and antibacterial properties.

摘要: Novel polyelectrolyte complexes (PECs) between N-carboxyethylchitosan (CECh) and well-defined (quaternized) poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) have been obtained. The modification of chitosan into CECh allows the preparation PECs in a pH range which cannot form complexes. CECh/PDMAEMA complex is formed narrow around 7. quaternization tertiary amino groups PDMAEMA enables formation with both neutral alkaline medium. Cross-linked also capable forming PDMAEMA. antibacterial activity (cross-linked) CECh, PDMAEMA, their against Escherichia coli has evaluated. In contrast to exhibits no activity. cross-linked results loss inherent latter acidic medium, exhibit strong due disintegration release