Linc02527 promoted autophagy in Intrahepatic cholestasis of pregnancy
作者： Jianguo Hu , Li Liu , Yangyang Gong , Lei Zhang , Xiaoling Gan
DOI: 10.1038/S41419-018-1013-Z
关键词:
摘要: LncRNA plays a crucial role in human disease. However, the expression and function of ICP(Intrahepatic cholestasis pregnancy) is still not fully elucidated. In this study, we found Linc02527 was increased placenta serum ICP patients. Ectopically promoted autophagy proliferate HTR8 cells. Silencing suppressed Mechanically study revealed that regulated ATG5 ATG7 by sponging miR-3185. directly binding to YBX1 activated P21. The growth C57 mouse retarded when activated. normal condition, inhibited using chloroquine did affect mouse. condition activated, can improve Overall, results identified as candidate biomarker potential target for therapy. Chloroquine drug
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