Immunoregulatory properties of vasoactive intestinal peptide in human T cell subsets: Implications for rheumatoid arthritis
作者： Irene Gutiérrez-Cañas , Yasmina Juarranz , Begoña Santiago , Carmen Martínez , Rosa P Gomariz
DOI: 10.1016/J.BBI.2007.09.007
关键词:
摘要: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease whose pathogenesis not completely understood. Unbalanced Th1/Th2 T-cell polarization has been suggested to play pathogenetic role and therefore, modulation of potential therapeutic target. Vasoactive intestinal peptide (VIP) broadly distributed that exerts anti-inflammatory immunomodulatory effects, in the collagen-induced (CIA) murine model RA, ex vivo, synovial cells from RA patients. In present study, we have found polyclonal stimulation peripheral blood lymphocytes (PBL) patients produces higher levels mediators lower Th1 cytokines than PBL healthy controls; moreover, VIP negligible effects on produced by controls but favours Th2 profile enhanced IL-10 production after stimulation. increases IL-4 supernatant human CD4(+)CD45RA(+) cultured non-conditioned or Th2-conditioned situation. contrast, does modify these Th1-conditioned medium. summary, can differentially functional capacity inducing Th2/Treg differentiation depending their previous phenotype.
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