Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization.
作者： Sara Laserra , Abdul Basit , Piera Sozio , Lisa Marinelli , Erika Fornasari
DOI: 10.1016/J.IJPHARM.2015.03.001
关键词:
摘要: Abstract Solid lipid nanoparticles (SLNs) are considered very attractive drug-delivery systems (DDS) able to enhance the efficacy of some therapeutic agents in several pathologies difficult treat a conventional way. Starting from these evidences, this study describes preparation, physicochemical characterization, release, and vitro cytotoxicity stealth SLNs as innovative approach improve solubility absorption through gastrointestinal tract lipoyl–memantine (LA–MEM), potential anti-Alzheimer codrug. Physico-chemical properties LA–MEM loaded have been intensively investigated. Differential scanning calorimetry (DSC) was used clarify state crystalline structure formulation. The results obtained particles size analysis, polydispersity (PDI), zeta measurements allowed identification optimized formulation, which characterized by drug-lipid ratio 1:5, an average intensity diameter 170 nm, PDI 0.072, −33.8 mV, entrapment efficiency 88%. Moreover, stability release studies both simulated gastric fluid (SGF) intestinal (SIF), preliminary revealed that could represent candidate for vivo investigation DDS brain since it resulted devoid citotoxicity free
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