Clinical features of carriers of reciprocal chromosomal translocations involving chromosome 2: report of nine cases and review of the literature.

摘要: Objective To explore the clinical features of carriers chromosome 2 translocations, enabling informed genetic counseling these patients. Materials and methods Eighty-two male a translocation who were infertile or receiving fertility recruited. Cytogenetic analyses performed using G-banding. A search PubMed was to determine whether identified translocations on are involved in infertility. The relationships breakpoints with infertility recurrent pregnancy loss analyzed. Results Of 82 carriers, 9 (11%) translocation. Four cases had oligozoospermia infertility, while five normal semen. In an analysis literature, 55 patients also reviewed. Breakpoints at 2p13 2q31 observed six each, most common. 2p23, 2p13, 2p11.2, 2q31, 2q37 associated both pre-gestational gestational other Conclusions All correlated Carriers should therefore receive continue natural conception use different technologies available via assisted reproductive technology, such as preimplantation diagnosis.