The oxidative inactivation of cytochrome P450 in monooxygenase reactions.
作者： Irina I. Karuzina , Alexander I. Archakov
DOI: 10.1016/0891-5849(94)90245-3
关键词:
摘要: Possible mechanisms of cytochrome P450 self-inactivation during catalytic turnover have been considered. Two ways hemoprotein inactivation are so far known. The firts, studied extensively by many authors, is the formation active substrate intermediates, capable modifying heme and apoenzyme. second way, revealed quite recently resulting from uncoupled P450-catalyzed monooxygenase reactions, yet to be clarified. Briefly, it involves hydrogen peroxide in center, which interacts with enzyme associated Fe2+, thereby generating hydroxyl radicals that bleach modify This mechanism operates substrates forms partially coupled thus causing as a byproduct.
elsevier.com
sci-hub.se 参考文章(185)
Marcel Delaforge, Maryse Jaouen, Daniel Mansuy, Dual effects of macrolide antibiotics on rat liver cytochrome P-450. Induction and formation of metabolite-complexes: a structure-activity relationship. Biochemical Pharmacology. ,vol. 32, pp. 2309- 2318 ,(1983) , 10.1016/0006-2952(83)90178-8
JEAN-CLAUDE DREYFUS, AXEL KAHN, FANNY SCHAPIRA, Posttranslational modifications of enzymes. Current Topics in Cellular Regulation. ,vol. 14, pp. 243- 297 ,(1978) , 10.1016/B978-0-12-152814-0.50010-1
P R Ortiz de Montellano, B L Mangold, C Wheeler, K L Kunze, N O Reich, Stereochemistry of cytochrome P-450-catalyzed epoxidation and prosthetic heme alkylation. Journal of Biological Chemistry. ,vol. 258, pp. 4208- 4213 ,(1983) , 10.1016/S0021-9258(18)32607-3
L J DeFilippi, D P Ballou, D E Hultquist, Reaction of bovine erythrocyte green hemoprotein with oxygen and hydrogen peroxide. Journal of Biological Chemistry. ,vol. 254, pp. 6917- 6923 ,(1979) , 10.1016/S0021-9258(18)50262-3
Ronald W. Estabrook, Jurgen Werringloer, ACTIVE OXYGEN—FACT OR FANCY Microsomes and Drug Oxidations#R##N#Proceedings of the Third International Symposium, Berlin, July 1976. pp. 748- 757 ,(1977) , 10.1016/B978-0-08-021523-5.50102-4
A. JENNIFER RIVETT, Regulation of Intracellular Protein Turnover: Covalent Modification as a Mechanism of Marking Proteins for Degradation Current Topics in Cellular Regulation. ,vol. 28, pp. 291- 337 ,(1986) , 10.1016/B978-0-12-152828-7.50010-X
G. Heinemeyer, A.G. Hildebrandt, I. Roots, S. Nigam, STOICHIOMETRY OF MIXED FUNCTION OXIDASE-DEPENDENT HYDROXYLATION OF HEXOBARBITAL Microsomes, Drug Oxidations and Chemical Carcinogenesis. pp. 331- 334 ,(1980) , 10.1016/B978-0-12-187701-9.50063-2
A. G. Hildebrandt, C. Bergs, G. Heinemeyer, E. Schlede, I. Roots, B. Abbas-Ali, A. Schmoldt, Studies on the Mechanism of Stimulation of Microsomal H2O2 Formation and Benzo(a)pyrene Hydroxylaton by Substrates and Flavone Advances in Experimental Medicine and Biology. pp. 179- 198 ,(1982) , 10.1007/978-1-4757-0674-1_11
Ivar Roots, Gabriele Laschinsky, Alfred G. Hildebrandt, Gerhard Heinemeyer, Santosh Nigam, INHIBITION OF HEXOBARBITAL-INDUCED MICROSOMAL H2O2 PRODUCTION BY METYRAPONE Microsomes, Drug Oxidations and Chemical Carcinogenesis. pp. 375- 378 ,(1980) , 10.1016/B978-0-12-187701-9.50074-7
A I Cederbaum, E Dicker, Inhibition of microsomal oxidation of alcohols and of hydroxyl-radical-scavenging agents by the iron-chelating agent desferrioxamine Biochemical Journal. ,vol. 210, pp. 107- 113 ,(1983) , 10.1042/BJ2100107