Magnetic resonance imaging of human melanoma xenografts in vivo: proton spin-lattice and spin-spin relaxation times versus fractional tumour water content and fraction of necrotic tumour tissue.
作者： E.K. Rofstad , E. Steinsland , O. Kaalhus , Y.B. Chang , B. Høvik
DOI: 10.1080/09553009414550451
关键词:
摘要: Proton nuclear magnetic resonance (1H-nmr) imaging is used routinely in clinical oncology to provide macroscopic anatomical information, whereas its potential physiological information about tumours not well explored. To evaluate the usefulness of 1H-nmr prediction tumour treatment resistance caused by unfavourable microenvironmental conditions, possible correlations between proton spin—lattice and spin-spin relaxation times (T1 T2) parameters microenvironment were investigated. Tumours from six human melanoma xenograft lines included study. was performed at 1·5T using spin—echo pulse sequences. T1- T2-distributions generated images. Fractional water content fraction necrotic tissue measured immediately after imaging. Significant across found for T1 T2 versus fractional (p < 0·001) as ...
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