Interaction of the La(III)–Morin Complex with Human Serum Albumin

摘要: Lanthanum (La) is one of the most reactive rare earth elements, whose carbonate had been approved by FDA for marketing as a treatment drug hyperphosphatemia. In this paper, complex La with natural active compound morin was synthesized and identified. The interaction between (LaMO) human serum albumin (HSA) studied multiple spectroscopic methods. It found that LaMO has an efficient HSA through hydrogen bonds van der Waals forces, formation LaMO–HSA in its ground state. reaction led to quenching HSA’s fluorescence follows static mechanism. binding constants, reference state enthalpy change (ΔH θ), Gibbs energy (ΔG θ) entropy (ΔS were calculated at four different temperatures. Fluorescence probe techniques used identify location. results showed competes warfarin Sudlow’s site I subdomain IIA HSA, acknowledged marker. Meanwhile, circular dichroism spectrum measurements revealed changes secondary structure presence LaMO, which implies potentially bioactive. study involves research about pharmacologic mechanism metal coordination compounds can provide basic data their safety evaluation.