Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm.
作者： R. E. Ayer , J. H. Zhang
DOI: 10.1007/978-3-211-75718-5_7
关键词:
摘要: Aneurismal subarachnoid haemorrhage (SAH) is a devastating disease that associated with significant morbidity and mortality. The mortality approximately 50%, 30% of survivors having morbidity. There substantial evidence to suggest oxidative stress in the development acute brain injury cerebral vasospasm following SAH. are several sources for excessive generation free radicals SAH, including disrupted mitochondrial respiration extracellular hemoglobin. also upregulation radical producing enzymes such as inducible nitric oxide synthase (iNOS), xanthine oxidase, NADPH oxidase (NOX), well involved metabolism arachidonic acid. Additionally, intrinsic antioxidant systems superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) inhibited. Experiments have linked apoptosis neurons endothelial cells, BBB breakdown altered contractile response vessels Antioxidant therapy has provided neuroprotection antispasmotic effects experimental SAH some therapies demonstrated improved outcomes clinical trials. These studies laid foundation use antioxidants treatment aneurismal
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R. Rodriguez y Baena, P. Gaetani, V. Silvani, G. Spanu, F. Marzatico, Effect of Nimodipine on Mitochondrial Respiration in Different Rat Brain Areas After Subarachnoid Haemorrhage Proceedings of the 8th European Congress of Neurosurgery, Barcelona, September 6–11, 1987. ,vol. 43, pp. 177- 181 ,(1988) , 10.1007/978-3-7091-8978-8_38
Fabrizio Facchinetti, Valina L. Dawson, Ted M. Dawson, In Vitro and In Vivo Effects of Genistein on Murine Alveolar Macrophage TNFα Production Inflammation. ,vol. 23, pp. 231- 239 ,(1999) , 10.1023/A:1020221919154
Takeshi Nishino, Isao Tamura, The Mechanism of Conversion of Xanthine Dehydrogenase to Oxidase and the Role of the Enzyme in Reperfusion Injury Advances in Experimental Medicine and Biology. pp. 327- 333 ,(1991) , 10.1007/978-1-4899-2638-8_74
R. P. Ostrowski, A. R. T. Colohan, J. H. Zhang, Neuroprotective effect of hyperbaric oxygen in a rat model of subarachnoid hemorrhage. Acta Neurochirurgica. ,vol. 96, pp. 188- 193 ,(2006) , 10.1007/3-211-30714-1_41
Zuo‐li Xia, Liang‐zhen Zhu, Su‐ming Zhang, Ping‐ming Qiu, Ming‐feng Yang, Bao‐liang Sun, Alleviation of brain edema by L-arginine following experimental subarachnoid hemorrhage in a rat model. Clinical Hemorheology and Microcirculation. ,vol. 29, pp. 437- 443 ,(2003)
L. J. Forman, P. Liu, R. G. Nagele, K. Yin, P. Y-K Wong, Augmentation of Nitric Oxide, Superoxide, and Peroxynitrite Production During Cerebral Ischemia and Reperfusion in the Rat Neurochemical Research. ,vol. 23, pp. 141- 148 ,(1998) , 10.1023/A:1022468522564
Stuart A. Lipton, David J. Singel, Jonathan S. Stamler, Chapter 29 Nitric oxide in the central nervous system Neural Regeneration. ,vol. 103, pp. 359- 364 ,(1994) , 10.1016/S0079-6123(08)61149-8
Fabrizio Facchinetti, Valina L. Dawson, Ted M. Dawson, FREE RADICALS AS MEDIATORS OF NEURONAL INJURY Cellular and Molecular Neurobiology. ,vol. 18, pp. 667- 682 ,(1998) , 10.1023/A:1020685903186
Barry Halliwell, Superoxide-dependent formation of hydroxyl radicals in the presence of iron chelates: is it a mechanism for hydroxyl radical production in biochemical systems? FEBS Letters. ,vol. 92, pp. 321- 326 ,(1978) , 10.1016/0014-5793(78)80779-0
Koji Osuka, Yoshio Suzuki, Yasuo Watanabe, Masakazu Takayasu, Jun Yoshida, Inducible Cyclooxygenase Expression in Canine Basilar Artery After Experimental Subarachnoid Hemorrhage Stroke. ,vol. 29, pp. 1219- 1222 ,(1998) , 10.1161/01.STR.29.6.1219