Gene polymorphisms of the renin-angiotensin-aldosterone system and the risk of ischemic stroke: a role of the A1166C/AT1 gene variant.

摘要: Objective The role of the renin-angiotensin-aldosterone system (RAAS) genes on predisposition to develop stroke, a multifactorial and polygenic cardiovascular trait, is still under investigation. In present study we characterized contributory RAAS in susceptibility ischemic stroke humans. Methods Allele genotype frequencies were population 215 cases (including only atherothrombotic lacunar forms) 236 controls selected Sardinia, large Mediterranean island with well-known segregated population. Statistical analysis was performed whole and, based significant interaction between angiotensin II receptor (AT1) hypertension, also repeated hypertensive subgroup. Results A association C1166/AT1 gene allelic variant found when assuming dominant model transmission [unadjusted odds ratio (OR) = 1.5, 95% confidence interval (Cl) 1.1-2.2, P 0.024]. strength became more evident subgroup individuals (135 110 controls). fact, this cohort independent OR for AT1 2.1, Cl 1.2-3.7, 0.006 2.0, 1.3-3.2, P= 0.002 additive model. No other identified as contributor stroke. Conclusions Our findings support predisposing an development particular, exerted major impact occurrence presence hypertension.