Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase.
作者： Patricia Saenz-Mendez , Per-Olof Syrén , Antonino Biundo , Elton P. Hudson , Robert Schnell
DOI: 10.1021/JACS.0C10214
关键词:
摘要: … model we could shed light on the structure–activity relationship of the class I cyclization cascade displayed by SvS. By studying … terpene cyclases, such as domain-swapping studies, …
acs.org
sci-hub.st 参考文章(84)
Anastassis Perrakis, Richard Morris, Victor S. Lamzin, Automated protein model building combined with iterative structure refinement. Nature Structural & Molecular Biology. ,vol. 6, pp. 458- 463 ,(1999) , 10.1038/8263
G.N. Ramachandran, V. Sasisekharan, Conformation of Polypeptides and Proteins Advances in Protein Chemistry. ,vol. 23, pp. 283- 438 ,(1968) , 10.1016/S0065-3233(08)60402-7
Jason H. Whitfield, William H. Zhang, Michel K. Herde, Ben E. Clifton, Johanna Radziejewski, Harald Janovjak, Christian Henneberger, Colin J. Jackson, Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction. Protein Science. ,vol. 24, pp. 1412- 1422 ,(2015) , 10.1002/PRO.2721
Rainer Merkl, Reinhard Sterner, Ancestral protein reconstruction: techniques and applications. Biological Chemistry. ,vol. 397, pp. 1- 21 ,(2016) , 10.1515/HSZ-2015-0158
U. M. Chandrasekharan, S. Sanker, M. J. Glynias, S. S. Karnik, A. Husain, Angiotensin II-Forming Activity in a Reconstructed Ancestral Chymase Science. ,vol. 271, pp. 502- 505 ,(1996) , 10.1126/SCIENCE.271.5248.502
David J. Miller, Rudolf K. Allemann, Sesquiterpene synthases: Passive catalysts or active players? Natural Product Reports. ,vol. 29, pp. 60- 71 ,(2012) , 10.1039/C1NP00060H
Valeria A. Risso, Jose A. Gavira, Diego F. Mejia-Carmona, Eric A. Gaucher, Jose M. Sanchez-Ruiz, Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian β-lactamases. Journal of the American Chemical Society. ,vol. 135, pp. 2899- 2902 ,(2013) , 10.1021/JA311630A
Philipp Baer, Patrick Rabe, Christian A. Citron, Carina C. de Oliveira Mann, Norman Kaufmann, Michael Groll, Jeroen S. Dickschat, Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism. ChemBioChem. ,vol. 15, pp. 213- 216 ,(2014) , 10.1002/CBIC.201300708
R. V. H. Jones, M. D. Sutherland, Hedycaryol, the precursor of elemol Chemical Communications (london). pp. 1229- 1230 ,(1968) , 10.1039/C19680001229
Florian Garczarek, Klaus Gerwert, Functional waters in intraprotein proton transfer monitored by FTIR difference spectroscopy Nature. ,vol. 439, pp. 109- 112 ,(2006) , 10.1038/NATURE04231