Chapter 25 Modulation of brain aging correlates by long-term alterations of adrenal steroids and neurally-active peptides

摘要: Publisher Summary Many mammalian cell systems deteriorate or cease functioning in vivo before the deterioration is necessitated by intrinsic cellular processes. There are circulating factors plasma that can modulate rate of age-dependent some systems. Some factor(s) essential to normal function may be lacking aging animals or, alternatively, accelerates age-related become more effective aged animals. Although study long-term effects adrenal steroids and neuropeptides new, increasing evidence indicates chronic exposure steroid peptide hormones alter adult brain structure function, modify on brain. at least these receptor-mediated, mediated neural activity. However, a substantial amount additional research required elucidate mechanisms hormonal actions function.