Response of tissue diamine oxidase activity to polyamine administration

摘要: The administration to rats of putrescine (750 mumol/kg body wt.) caused in liver, kidney and heart an increase at 1 h diamine oxidase (EC 1.4.3.6) activity within 3-6 h. An spermidine was observed 9 liver 6 kidney, whereas there no change. by exogenous prevented the actinomycin D cycloheximide, suggesting that syntheses mRNA protein are involved. Equimolar doses 1,3-diaminopropane, 1,5-diaminopentane monoacetylputrescine stimulated, similarly putrescine, hepatic, renal cardiac activity. After injection a non-toxic dose wt.), occurred all tissues studied, when substantial formation from occurred. sym-Norspermidine, which is unable form did not cause enzyme possibility tissue contents might regulate discussed.