Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3.
作者： Z Q Ma , S Santagati , C Patrone , G Pollio , E Vegeto
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摘要: The neuroblastoma cell line SK-ER3, which is stably transfected with the estrogen receptor (ER), was used to study effect of insulin and insulin-like growth factors (IGF-I IGF-II) on morphological differentiation induced by estrogens. data demonstrate that related control expressing ER, but not parental line. Effects elicited in SK-ER3 cells can be blocked ER antagonists. Transient transfection studies further confirm an IGFs modulation ER-activated promoters. results presented support hypothesis existence cross-talk between membrane intracellular receptors provide evidence for physiological consequences activation such a pathway communication. present particular interest regard theory prenatal involvement maturation nerve cells. It could, fact, be...
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sci-hub.se 参考文章(17)
E. Vegeto, R. Fontanelli, F. Raspagliesi, A. Maggi, A. Piffanelli, M. G. Cocciolo, Regulation of Progesterone Receptor Gene Expression Cancer Research. ,vol. 50, pp. 5291- 5295 ,(1990)
A Ferreira, A Caceres, Estrogen-enhanced neurite growth: Evidence for a selective induction of tau and stable microtubules The Journal of Neuroscience. ,vol. 11, pp. 392- 400 ,(1991) , 10.1523/JNEUROSCI.11-02-00392.1991
Z. Q. Ma, E. Spreafico, G. Pollio, S. Santagati, E. Conti, E. Cattaneo, A. Maggi, Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 3740- 3744 ,(1993) , 10.1073/PNAS.90.8.3740
Adriana Maggi, Jorge Perez, Role of female gonadal hormones in the CNS: clinical and experimental aspects. Life Sciences. ,vol. 37, pp. 893- 906 ,(1985) , 10.1016/0024-3205(85)90525-9
Masayuki Uchibori, Seiichiro Kawashima, Effects of sex steroids on the growth of neuronal processes in neonatal rat hypothalamus-preoptic area and cerebral cortex in primary culture. International Journal of Developmental Neuroscience. ,vol. 3, pp. 169- 176 ,(1985) , 10.1016/0736-5748(85)90007-3
C. Dominique Toran-Allerand, Sex steroids and the development of the newborn mouse hypothalamus and preoptic areain vitro: implications for sexual differentiation Brain Research. ,vol. 106, pp. 407- 412 ,(1976) , 10.1016/0006-8993(76)91038-6
B. Vannier, J.P. Raynaud, Effect of estrogen plasma binding on sexual differentiation of the rat fetus. Molecular and Cellular Endocrinology. ,vol. 3, pp. 323- 337 ,(1975) , 10.1016/0303-7207(75)90034-9
SUSAN M. ARONICA, BENITA S. KATZENELLENBOGEN, Progesterone receptor regulation in uterine cells: stimulation by estrogen, cyclic adenosine 3',5'-monophosphate, and insulin-like growth factor I and suppression by antiestrogens and protein kinase inhibitors. Endocrinology. ,vol. 128, pp. 2045- 2052 ,(1991) , 10.1210/ENDO-128-4-2045
A. Baron-Van Evercooren, C. Olichon-Berthe, A. Kowalski, G. Visciano, E. Van Obberghen, Expression of IGF-I and insulin receptor genes in the rat central nervous system: a developmental, regional, and cellular analysis. Journal of Neuroscience Research. ,vol. 28, pp. 244- 253 ,(1991) , 10.1002/JNR.490280212
C.Dominique Toran-Allerand, Leland Ellis, Karl H. Pfenninger, Estrogen and insulin synergism in neurite growth enhancement in vitro: mediation of steroid effects by interactions with growth factors? Developmental Brain Research. ,vol. 41, pp. 87- 100 ,(1988) , 10.1016/0165-3806(88)90172-1