Vaccinia and other viruses with available vaccines show marked homology with the HIV-1 envelope glycoprotein: the prospect of using existing vaccines to stem the AIDS pandemic.
DOI: 10.3109/08923973.2011.596542
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摘要: Cross-reactive immunity occurs when infection with or vaccination against one virus protects another related family member. A search for homologues of the HIV-1 envelope glycoprotein revealed that it is composed thousands intercalating and overlapping viral matches pentapeptide longer gapped consensi, belonging to over 70% currently sequenced virome, infecting all kingdoms from bacteria man. It was also highly homologous proteins Visna/Maedi other ovine viruses, while (nef/tat/gag/pol) were equine infectious anaemia HTLV-2/HTLV-3 viruses. This phenomenon suggests horizontal gene transfer coinfecting RNA DNA viruses retroviruses extensive, providing a route subsequent insertion non-retroviral genes into human genomes via retroviral integration. homology includes which vaccines already exist. may be operative in AIDS, as ...
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