Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform
作者： C.-M. J. Hu , L. Zhang , S. Aryal , C. Cheung , R. H. Fang
关键词:
摘要: Efforts to extend nanoparticle residence time in vivo have inspired many strategies particle surface modifications bypass macrophage uptake and systemic clearance. Here we report a top-down biomimetic approach functionalization by coating biodegradable polymeric nanoparticles with natural erythrocyte membranes, including both membrane lipids associated proteins for long-circulating cargo delivery. The structure, size zeta potential, protein contents of the membrane-coated were verified using transmission electron microscopy, dynamic light scattering, gel electrophoresis, respectively. Mice injections fluorophore-loaded revealed superior circulation half-life erythrocyte-mimicking as compared control particles coated state-of-the-art synthetic stealth materials. Biodistribution study significant retention blood 72 h following injection. translocation cellular their proteins, corresponding functionalities represents unique functionalization.
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