Biological Aging in Childhood and Adolescence Following Experiences of Threat and Deprivation: A Systematic Review and Meta-Analysis

摘要: Life history theory argues that exposure to early-life adversity (ELA) accelerates development, although existing evidence for this varies. We present a meta-analysis and systematic review testing the hypothesis ELA involving threat (e.g., violence exposure) will be associated with accelerated biological aging across multiple metrics, whereas deprivation neglect, institutional rearing) low-socioeconomic status (SES) not. meta-analyze 46 studies (n=64,925) examining associations of pubertal timing cellular (telomere length DNA methylation age), systematically 19 (n=2276) neural markers development (cortical thickness amygdala-prefrontal cortex functional connectivity) evaluate whether vary according nature experienced. overall was (d=-0.12) (d=-0.32). Moderator analysis revealed characterized by (d=-0.26), but not or SES, development. Similarly, threat-related (d=-0.43), SES. Systematic between cortical thinning, consistently thinning in ventromedial prefrontal cortex, SES frontoparietal, default, visual networks. There no consistent association amygdala-PFC connectivity. These findings suggest specificity types early environmental experiences highlight importance evaluating how contributes health disparities process can mitigated through intervention.