AMP-activated protein kinase protects against anoxia in Drosophila melanogaster
作者： Justin J. Evans , Chengfeng Xiao , R. Meldrum Robertson
DOI: 10.1101/162719
关键词:
摘要: During anoxia, proper energy maintenance is essential in order to maintain neural operation. Starvation activates AMP-activated protein kinase (AMPK), an evolutionarily conserved indicator of cellular status, a cascade which modulates ATP production and consumption. We investigated the role energetic status on anoxia tolerance Drosophila discovered that starvation or AMPK activation increases speed locomotor recovery from anoxic coma. Using temporal spatial genetic targeting we found fat body contributes starvation-induced fast recovery, whereas, under fed conditions, disrupting oenocytes prolongs recovery. By evaluating spreading depolarization fly brain during show reduces severity ionic disruption electrical activity. Further indicates glial, but not neuronal, affects Together, these findings support model neuroprotective .
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