Organ-based drug delivery.

摘要: The phenomenal advances in pharmaceutical sciences over the last few decades have led to development of new therapeutics like peptides, proteins, RNAs, DNAs and highly potent small molecules. Fruitful applications these been challenged by several anatomical physiological barriers that limit adequate drug disposition at site-of-action off-target distribution undesired tissues, which together result reduced effectiveness increased side effects therapeutic agents. As such, delivery targeting systems has recognised as a cornerstone for future development. Research is now devoted tackling challenges through engineering move beyond conventional dosage forms regimens into state-of-the-art targeted tailored toward specific needs. Modern comprise passive active approaches. While relies on natural course drugs or carriers body, governed their physicochemical properties, often exploits moieties home preferentially target tissues. Here, we provide an overview theories approaches delivery. design dependent unique structure tissues organs, present our discussion organ-specific manner with aim inspire strategies curing disease high accuracy efficiency.