Association of viral hepatitis and bipolar disorder: a nationwide population-based study

摘要: Bipolar disorder (BD), a type of psychiatric mood disorder, is manifested by chronic and recurrent fluctuations. This study aims to determine whether hepatitis B virus (HBV) or C (HCV) infection risk factor for BD. A total 48,215 patients with newly diagnosed viral from 2000 2010 were identified frequency-matched 192,860 people without hepatitis. Both groups followed until diagnosis BD, withdrawal the national health insurance program, end 2011. Patients grouped into 3 cohorts: HBV infection, HCV HBV/HCV coinfection. The association between BD examined using Cox proportional hazards regression models. incidence was higher in coinfection than control group, an adjusted hazard ratio 2.16 (95% confidence interval 1.06–4.41) when sex, age, comorbidity. After further adjustment, we noted that age more 65 years female may be associated increased C. Viral subsequent