Effects of oral furosemide and salt loading on parathyroid function in normal subjects. Physiological basis for renal hypercalciuria.

摘要: With oral furosemide administration and salt loading, urinary calcium was significantly increased in 8 normal subjects, accompanied by parallel natriuresis. In spite of the excessive loss urine, total ionized serum remained unchanged. All subjects had significant increases nephrogenous cyclic AMP, suggesting that parathyroid activity is elevated with furosemide-induced hypercalciuria. furosemide, fecal decreased, resultantly, there no change cumulative balance. It suggested compensated for secondary hyperparathyroidism via intestinal absorption order to maintain at a level. The experimental model thus mimics condition renal type idiopathic