Temporal trends and determinants of longitudinal change in 25-hydroxyvitamin D and parathyroid hormone levels.
作者： Claudie Berger , Linda S Greene-Finestone , Lisa Langsetmo , Nancy Kreiger , Lawrence Joseph
DOI: 10.1002/JBMR.1587
关键词:
摘要: Vitamin D is essential for facilitating calcium absorption and preventing increases in parathyroid hormone (PTH), which can augment bone resorption. Our objectives were to examine serum levels of 25-hydroxyvitamin [25(OH)D] PTH, factors related longitudinal change a population-based cohort. This the first study looking at PTH 25(OH)D levels. We analyzed 3896 blood samples from 1896 women 829 men Canadian Multicentre Osteoporosis Study over 10-year period starting 1995 1997. fit hierarchical models with all available data adjusted season. Over 10 years, vitamin supplement intake increased by 317 (95% confidence interval [CI] 277 359) IU/day 193 (135 252) men. Serum (without adjustment) 9.3 (7.3 11.4) nmol/L 3.5 (0.6 6.4) but 4.7 (2.4 7.0) 2.7 (−0.6 6.2) after adjustment supplements. The percentage participants <50 was 29.7% (26.2 33.2) baseline 19.8% (18.0 21.6) year follow-up. decreased years 7.9 (5.4 11.3) pg/mL 4.6 (0.2 9.0) Higher associated summer, younger age, lower body mass index (BMI), regular physical activity, sun exposure, higher total intake. Lower age both BMI participation activity only. have observed concurrent increasing decreasing years. Secular supplemental influenced changes © 2012 American Society Bone Mineral Research.
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