TRPC channels: Structure, function, regulation and recent advances in small molecular probes.

作者: Hongbo Wang , Xiaoding Cheng , Jinbin Tian , Yuling Xiao , Tian Tian

DOI: 10.1016/J.PHARMTHERA.2020.107497

关键词:

摘要: … the understanding of TRPC channel regulation, structure, and discovery of novel TRPC small molecular probes … The effects of PIP 2 on TRPC activation are complex. On one hand, the …

参考文章(364)
Nicole Urban, Liming Wang, Sandra Kwiek, Jörg Rademann, Wolfgang M. Kuebler, Michael Schaefer, Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor. Molecular Pharmacology. ,vol. 89, pp. 197- 213 ,(2016) , 10.1124/MOL.115.100792
Dong-xu He, Xin Ma, Transient receptor potential channel C5 in cancer chemoresistance Acta Pharmacologica Sinica. ,vol. 37, pp. 19- 24 ,(2016) , 10.1038/APS.2015.109
Dhananjay P. Thakur, Jin-bin Tian, Jaepyo Jeon, Jian Xiong, Yu Huang, Veit Flockerzi, Michael X. Zhu, Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 113, pp. 1092- 1097 ,(2016) , 10.1073/PNAS.1522294113
Seishiro Sawamura, Masahiko Hatano, Yoshinori Takada, Kyosuke Hino, Tetsuya Kawamura, Jun Tanikawa, Hiroshi Nakagawa, Hideharu Hase, Akito Nakao, Mitsuru Hirano, Rachapun Rotrattanadumrong, Shigeki Kiyonaka, Masayuki X. Mori, Motohiro Nishida, Yaopeng Hu, Ryuji Inoue, Ryu Nagata, Yasuo Mori, Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds Molecular Pharmacology. ,vol. 89, pp. 348- 363 ,(2016) , 10.1124/MOL.115.102863
Jae-Pyo Jeon, Dhananjay P. Thakur, Jin-bin Tian, Insuk So, Michael X. Zhu, Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o Biochemical Journal. ,vol. 473, pp. 1379- 1390 ,(2016) , 10.1042/BCJ20160214
Marc Riehle, Anja K. Büscher, Björn-Oliver Gohlke, Mario Kaßmann, Maria Kolatsi-Joannou, Jan H. Bräsen, Mato Nagel, Jan U. Becker, Paul Winyard, Peter F. Hoyer, Robert Preissner, Dietmar Krautwurst, Maik Gollasch, Stefanie Weber, Christian Harteneck, TRPC6 G757D Loss-of-Function Mutation Associates with FSGS Journal of The American Society of Nephrology. ,vol. 27, pp. 2771- 2783 ,(2016) , 10.1681/ASN.2015030318
Jongyun Myeong, Juyeon Ko, Chansik Hong, Dongki Yang, Kyu Pil Lee, Ju-hong Jeon, Insuk So, The interaction domains of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heteromultimeric channels. Biochemical and Biophysical Research Communications. ,vol. 474, pp. 476- 481 ,(2016) , 10.1016/J.BBRC.2016.04.138
Hong-Ni Jiang, Bo Zeng, Gui-Lan Chen, Bin Lai, Shao-Hua Lu, Jie-Ming Qu, Lipopolysaccharide potentiates endothelin-1-induced proliferation of pulmonary arterial smooth muscle cells by upregulating TRPC channels. Biomedicine & Pharmacotherapy. ,vol. 82, pp. 20- 27 ,(2016) , 10.1016/J.BIOPHA.2016.04.055
Shengjie Feng, Zhuohao He, Hongyu Li, Yizheng Wang, Ca2+ signaling initiated by canonical transient receptor potential channels in dendritic development Neuroscience Bulletin. ,vol. 31, pp. 351- 356 ,(2015) , 10.1007/S12264-014-1511-7