Meeting of the minds: Metalloneurochemistry

作者: S. C. Burdette , S. J. Lippard

DOI: 10.1073/PNAS.0637711100

关键词:

摘要: Metalloneurochemistry is the study of metal ion function in brain and nervous system at molecular level. Research this area exemplified through discussion several forefront areas where significant progress has been made recent years. The structure channels have elucidated high-resolution x-ray structural work on bacterial K+ channel. Selection potassium over sodium ions achieved by taking advantage key principles coordination chemistry. role calcium neuronal signal transduction effected Ca2+-binding protein such as calmodulin, calcineurin, synaptotagmin. Structural changes response to concentrations allow these proteins memory formation other neurochemical roles. Metallochaperones help achieve homeostasis thus prevent neurological diseases because imbalance. Much detailed chemical information about systems become available recently. Zinc another important neuroscience. Its concentration part controlled metallothionein, zinc released hippocampus glutamatergic synapses. New fluorescent sensors track release.

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