Germ Cell Tumors in Adolescents and Young Adults.

摘要: Germ cell tumors (GCTs) represent a group of biologically complex malignancies that affect patients at different sites within the body and ages. The varying nature these reflects their origin which is primordial germ cell, normally gives rise to ovarian testicular egg sperm producing cells. These cells retain an ability give all types human tissues, this illustrated by kinds GCTs occur. In adolescent young adult (AYA) patients, predominantly present as testicular, or mediastinal primary GCTs, some most therapeutic challenges any AYA practice. defined site and/or age presentation, can look very similar microscopically. However, there growing evidence they may have molecular characteristics, biology requirements for curative treatments. Whilst in environmental cause during fetal development genetic component, causative factors are much less well understood other GCTs. curable cancers adults, but exhibit resistance standard Because this, today's clinical research directed understanding how best utilize toxic therapies promote healthy survivorship. This chapter explores biology, behavior treatment discusses hold keys fundamental unanswered questions biological variance curability