Cancer metabolomics in basic science perspective.

摘要: As metabolomics investigates metabolic pathways with the focus on metabolites, it is a suitable approach to address complex alteration in cancer. In addition, profiles are affected by environmental and post-natal changes, therefore, directly measuring many metabolites may provide epigenetically relevant information Despite much development our understanding of cancer metabolism, often directed signaling or proteins that modulate metabolite levels. this review, we discuss “metabolite-oriented view” metabolism. We cover how research contributed current insights into basic mechanism alterations leading Then, specific related enzymatic tumorigenesis. particularly pay attention regulate enzymes ultimately phenotypes. Finally, future prospects challenges research.