Parametric investigations of the effects of prior exposure to amphetamine and morphine on conditioned gustatory aversion.

作者: Howard Cappell , A. E. Le Blanc

DOI: 10.1007/BF00431634

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摘要: Pretreatment by a psychoactive drug can greatly attenuate the conditioning of gustatory avoidance that drug. Although such findings have been interpreted in terms tolerance, alternative explantions are possible. In series experiments, it was found pretreatments with morphine or amphetamine massed at 24-h intervals were no more effective attenuating than spaced 120-h intervals, but pretreatment provided persistent protection against subsequent itself did comparable previous experiment. The similarity and effects be without appealing to tolerance as factor, greater persistence implicates mechanism.

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