Ins and outs of clinical trials with peptide-based vaccines

摘要: Peptides are the smallest antigenic components that recognized by T cells when presented in MHC molecules on cell surface. After identification of peptides from tumor associated and specific antigens, exploration use immunotherapy cancer was instigated. From initial peptide-mediated induction immune responses mice, peptide based vaccines have evolved to clinical testing patients. Many different trials been performed address ability peptide-based induce both immunological This review will provide an overview results majority with directed against various antigens patients solid tumors.