The Epidermal Growth Factor Receptor: Receptor Dimerization and Signal Transduction

摘要: The epidermal growth factor (EGF) receptor is a single chain transmembrane glycoprotein with ligand-dependent protein tyrosine kinase activity (Carpenter, 1987). Activation of the essential, although not necessarily sufficient, for multiple biological effects EGF (Chen et al., 1987; Moolenaar al.,1988). Early events induced by include tyrosine-specific phosphorylations, inositol lipid breakdown, changes in cytoplasmic pH and free Ca2+ alterations membrane potential Chen al, 1986 1988; Rothenberg 1982; Tilly Pandiella 1989). This chapter briefly summarizes our recent findings on two aspects function: activation emphasis proposed role ‘receptor dimerization’ post-receptor signal transduction, particularly phosphoinositide-specific phospholipase C.