Targeting Cellular Stress Mechanisms and Metabolic Homeostasis by Chinese Herbal Drugs for Neuroprotection.

摘要: Traditional Chinese medicine has been practiced for centuries in East Asia. Herbs are used to maintain health and cure disease. Certain herbs known protect improve the brain, memory, nervous system. To apply ancient knowledge modern science, some major natural therapeutic compounds were extracted evaluated recent decades. Emerging studies have shown that herbal neuroprotective effects or can ameliorate neurodegenerative diseases. understand mechanisms of against diseases, we summarize discovered neuroprotection by compound-related disease models. Those discussed herein show through different mechanisms, such as cytokine regulation, autophagy, endoplasmic reticulum (ER) stress, glucose metabolism, synaptic function. The interleukin (IL)-1β tumor necrosis factor (TNF)-α signaling pathways inhibited compounds, thus attenuating inflammatory response protecting neurons from cell death. As autophagy opposite regulatory Herbal inhibit ER stress prevent neuronal death Moreover, there affecting metabolism Since progression diseases is complicated, differ, strategies may need involve multiple consider type stage