MyosinX is Required For Craniofacial Development in Danio Rerio

摘要: Craniofacial development is the process of laying early cartilage and bone patterns in anterior region embryo, which ultimately results shaping structure face head an organism. abnormalities humans, such as cleft lip palate, are among most common all birth defects. Therefore, investigating molecular mechanisms involved craniofacial will help us understand both evolutionary processes genetic diseases. structures almost entirely derived from neural crest cells. Neural a pluripotent migratory stream cells that originate developing brain settle final positions give rise to future skull face. Several motor proteins implicated migration these We have identified isolated zebrafish myosinX mutants with defective development. Currently, we characterizing role using various staining techniques. Alcian blue was used identify specific defects within cartilage, specifically ceratobranchial arches 3-5 distorted or completely missing deficient embryos. Using alizarin red techniques, pharyngeal tooth also examined. Tooth occurs on fifth arch three crown clustered manner. However, zebrafish, protrusion significantly hindered, showing only one morphant This study