Consumption of guar gum and retrograded high-amylose corn resistant starch increases IL-10 abundance without affecting pro-inflammatory cytokines in the colon of pigs fed a high-fat diet.

摘要: Increases in dietary intake of viscous and nonviscous soluble fiber are reported to improve bowel health. However, related biological mechanisms not very clear. This study was conducted examine if colonic inflammation would occur a typical Western diet model determine consumption components attenuate potential detrimental effects by differentially affecting abundances anti-inflammatory cytokine IL-10 2 pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) IL-6 pigs fed high-fat basal supplemented, respectively, with 15% guar gum (GG) fiber, that is, retrograded high-amylose corn (Zea mays) resistant starch (RS). A total 24 Yorkshire growing barrows were assigned into standard soybean (Glycine max) meal (SBM)-based grower as positive control (PC), an animal protein-based the negative (NC), NC diets supplemented GG RS, according completely randomized block design for 4 wk. Abundance these homogenized extracted tissue supernatant samples measured ELISA. Although abundance lower (P 0.05) TNF-α between PC groups among all treatment groups. Compared group, RS at increased Thus, did induce inflammation. Diets or may protect colon from developing enhancing abundance.