Through Disturbances in Neuronal Arborization Prenatal Cerebral Ischemia Disrupts MRI-Defined Cortical Microstructure

摘要: €€€determine how differences in brain anatomy and MRI data translate into developmental cognitive outcomes.developing to develop methods for preventing any resulting injury. In addition, long-term studies should help More are needed understand postnatal growth, nutrition, illness, prenatal ischemia affect theneurons.disturbances the branching of neuronal dendrites abnormal formation synapse connections with other histological structural aberrations. The growth impairment seen animals' brains by corresponded toischemic episodes. Here, authors also saw abnormalities development correlated them after an utero ischemic event, these were compared those age-matched animals that did not undergogestation time. lambs analyzed both analysis at 1, 2, or 4 weeksstructures fetal had experienced a time about two-thirds full Dean et al. took different approach studying premature development: they brainillnesses infants may have early life.brain structure (and presumably nutrition) even accounting otherof infections serious illnesses. A detailed scans showed normal weight, length, head size−−as well as on factors could including presencedates scan when reached term. tracked infants' parameters−−The performed two sets infants: one was done 2 months before their due Vinall coauthors examined 95 newborn babies who born 24 32 weeks gestation.angles using diffusion tensor magnetic resonance imaging (MRI) human lambs.can be difficult predict. Now, obtained new this problem from differentcomplications. particular, problems delays common patient population Despite all recent advances medical care newborns, still often experienceEarly Start Better Brainsrights reserved. title Science Translational Medicine is registered trademark AAAS. NW, Washington, DC 20005. Copyright 2013 American Association Advancement Science; alllast week December, Science, 1200 New York Avenue (print ISSN 1946-6234; online 1946-6242) published weekly, except April 18, 2013stm.sciencemag.orgDownloaded