Modulation of receptor levels in canine breast tumors by administration of tamoxifen and etretinate either alone or in combination.

摘要: Steroid receptors were measured in a series of 30 operable canine mammary gland tumors; both cytoplasmic estrogen (ERc) and progesterone (PgRc) receptor mean concentrations very low with respect to the levels found humans. Therefore study was designed modulate by administration Tamoxifen Etretinate, either alone or combination. Forty dogs resectable, histologically documented tumors subdivided into following treatment groups: a. Etretinate (1 mg/kg/d) p.o. for 7 days followed (0.7 days; b. 14 c. d. placebo, ERc PgRc nuclear ER (ERn) before after treatment. An increase ERn observed Tamoxifen, while an only seen Etretinate. We conclude that are indeed hormone sensitive despite their suitable can fact levels. However, further studies needed better define optimal regimen order achieve maximal steroid induction.