Endometrial Carcinogenesis and Molecular Signaling Pathways
作者： Xianyong Ma , Charles X. Ma , Jianghui Wang
关键词:
摘要: The Endometrial Cancer (EC) is the most common gynecologic malignancy that starts in endometrium of women. Carcinogenesis EC associated with several critical regulatory molecules, which involve different signaling pathways. A number signaling pathways have been identified to be involved multiple-step development EC, including PI3K/AKT/mTOR signaling pathway, WNT/β-catenin signal transduction cascades (including APC/β-catenin pathway), MAPK/ERK VEGF/VEGFR ligand receptor ErbB P53/P21 and P16INK4a/pRB signaling This review mainly focuses on molecular relevant human endometrial cancer and discusses those capabilities transforming cells, including evading apoptosis; enhancing cell proliferation; blocking differentiation; and inducing angiogenesis.
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