Toxic peripheral neuropathy associated with commonly used chemotherapeutic agents.

摘要: Peripheral neuropathy ranks among the most common non-haematological adverse effects of a number effective chemotherapeutic agents, including platinum compounds, taxanes and vinca alkaloids. Newer such as bortezomib, thalidomide lenalidomide, frequently exert similar neurotoxic on peripheral nerves. Chemotherapy-induced (CIPN) may result from variety mechanisms be related to causal factors, single dose per course, cumulative risk factors treatment schedule, prior or concomitant administration other age pre-existing causes. The symptoms usually begin during chemotherapy they even worsen after cessation treatment. In cases, patients experience positive (pain, paresthesias) negative (numbness) sensory in distal extremities stocking-and-glove distribution with less prominent motor autonomic involvement. To date, several neuroprotective agents thiols, neurotrophic anticonvulsants antioxidants have been tested preclinical models clinical open label randomized controlled trials for their ability prevent treat CIPN. Although these hold promise possible data are still controversial none yet robustly proven against This review critically looks at pathogenesis, incidence, diagnosis, characteristics management associated commonly used agents. We also highlight areas future research pursue.