Association of Loneliness and Wisdom With Gut Microbial Diversity and Composition: An Exploratory Study.

摘要: Loneliness and wisdom have opposite effects on health well-being. is a serious public problem associated with increased morbidity mortality. Wisdom better We consistently found strong negative correlation between loneliness wisdom. The present study aimed to investigate the association of gut microbiome. One hundred eighty-four community-dwelling adults (28-97 years) completed validated self-report-based measures loneliness, wisdom, compassion, social support, engagement. Fecal samples were collected profiled using 16S rRNA sequencing. Linear regression analyses, controlling for age body mass index, revealed that lower levels higher engagement greater phylogenetic richness diversity Partial least squares (PLS) analysis multivariate relationships extracted two composite variables. model predicting alpha-diversity PLS components linear combination all psychosocial predictors (with loading positive loadings others, including engagement) was significantly alpha-diversity. For beta-diversity, compassion accounted significant proportion variance in overall microbial community composition. Findings may implications interventions reduce possibly its health-related adverse consequences. Future research should explore whether increasing improve well-being as well diversity.