The Pattern of Inhibin/Activin α- andβ B-Subunit Messenger Ribonucleic Acid Expression in Rat Testis after Selective Leydig Cell Destruction by Ethylene Dimethane Sulfonate1
作者： Manuel Tena-Sempere , Jukka Kero , Antti Rannikko , Wei Yan , Ilpo Huhtaniemi
关键词:
摘要: To further investigate the regulatory mechanisms responsible for control of testicular inhibin/activin subunit gene expression, inhibin-α, -βA, and -βB messenger RNA (mRNA) levels were assessed after ethylene dimethane sulfonate (EDS)-induced destruction Leydig cells (LC) in different animal models: intact rat, rat treated with high doses testosterone, unilaterally cryptorchid rat. In rats, EDS selectively eliminates mature adult-type LCs, activating proliferation differentiation preexisting LC precursors into a new population functionally active LCs. this model, single dose (75 mg/kg BW, ip) induced significant increase inhibin-α mRNA 5 days treatment (5.0- 5.5-fold increases, respectively), whereas inhibin-βA remained undetectable upon Northern hybridization EDS-treated testes. Moreover, situ analysis demonstrated that increased expression ...
oup.com
endocrine.org
sci-hub.se 参考文章(51)
WYLIE VALE, CATHERINE RIVIER, AARON HSUEH, CAROLYN CAMPEN, HELENE MEUNIER, THOMAS BICSAK, JOAN VAUGHAN, ANNE CORRIGAN, WAYNE BARDIN, PAUL SAWCHENKO, FELICE PETRAGLIA, JOHN YU, PAUL PLOTSKY, JOACHIM SPIESS, JEAN RIVIER, Chemical and biological characterization of the inhibin family of protein hormones. Recent Progress in Hormone Research. ,vol. 44, pp. 1- 34 ,(1988) , 10.1016/B978-0-12-571144-9.50005-3
T Nakamura, M Asashima, Y Eto, K Takio, H Uchiyama, N Moriya, T Ariizumi, T Yashiro, K Sugino, K Titani, Isolation and characterization of native activin B. Journal of Biological Chemistry. ,vol. 267, pp. 16385- 16389 ,(1992) , 10.1016/S0021-9258(18)42014-5
J Noguchi, H Hikono, S Sato, G Watanabe, K Taya, S Sasamoto, Y Hasegawa, Ontogeny of inhibin secretion in the rat testis: secretion of inhibin-related proteins from fetal Leydig cells and of bioactive inhibin from Sertoli cells. Journal of Endocrinology. ,vol. 155, pp. 27- 34 ,(1997) , 10.1677/JOE.0.1550027
Enrique Aguilar, Leonor Pinilla, Manuel Tena-Sempere, Growth Hormone-Releasing Hormone-Induced Growth Hormone Secretion in Adult Rats Orchidectomized or Injected with Ethylene Dimethane Sulphonate Neuroendocrinology. ,vol. 57, pp. 132- 134 ,(1993) , 10.1159/000126352
P. O'Leary, A.E. Jackson, S. Averill, D.M. de Kretser, The effects of ethane dimethane sulphonate (EDS) on bilaterally cryptorchid rat testes Molecular and Cellular Endocrinology. ,vol. 45, pp. 183- 190 ,(1986) , 10.1016/0303-7207(86)90146-2
E. J. CLEGG, STUDIES ON ARTIFICIAL CRYPTORCHIDISM: DEGENERATIVE AND REGENERATIVE CHANGES IN THE GERMINAL EPITHELIUM OF THE RAT TESTIS. Journal of Endocrinology. ,vol. 27, pp. 241- 251 ,(1963) , 10.1677/JOE.0.0270241
F. S. Esch, S. Shimasaki, K. Cooksey, M. Mercado, A. J. Mason, S.-Y. Ying, N. Ueno, N. Ling, Complementary Deoxyribonucleic Acid (cDNA) Cloning and DNA Sequence Analysis of Rat Ovarian Inhibins Molecular Endocrinology. ,vol. 1, pp. 388- 396 ,(1987) , 10.1210/MEND-1-5-388
B. Jegou, A. O. Laws, D. M. de Kretser, The effect of cryptorchidism and subsequent orchidopexy on testicular function in adult rats Reproduction. ,vol. 69, pp. 137- 145 ,(1983) , 10.1530/JRF.0.0690137
A. M. Ultee-van Gessel, F. G. Leemborg, F. H. de Jong, H. J. van der Molen, In-vitro secretion of inhibin-like activity by Sertoli cells from normal and prenatally irradiated immature rats. Journal of Endocrinology. ,vol. 109, pp. 411- 418 ,(1986) , 10.1677/JOE.0.1090411
A M Haavisto, K Pettersson, M Bergendahl, A Perheentupa, J F Roser, I Huhtaniemi, A supersensitive immunofluorometric assay for rat luteinizing hormone Endocrinology. ,vol. 132, pp. 1687- 1691 ,(1993) , 10.1210/ENDO.132.4.8462469