Protrusive Forces Generated by Dendritic Actin Networks During Cell Crawling

摘要: Cell protrusions during crawling motility involve growth of a dendritic actin network at the leading edge. Numerous studies over last several decades have revealed identity key proteins involved in networks and elucidated how these interact with each other assembly growth, enabling reconstitution vitro. While it is clear that can displace loads, mechanism dynamics force generation continue to be subject investigation. In this chapter we describe current theories for underlying by discuss experimental measurements quantify magnitude forces. Reconstitution played central role demonstrated combination small set leads complex history dependent growth. Measurements protrusion cells are now beginning test predictions studies. We conclude discussing integrated into an overall understanding cell motility.