Relationship of regional adiposity to insulin resistance and serum triglyceride levels in nonobese Japanese type 2 diabetic patients.

摘要: The aim of this study was to investigate the relationships between insulin resistance and regional abdominal fat area, body mass index (BMI), serum lipid profile in nonobese Japanese type 2 diabetic patients. A total 63 patients aged 45 83 years were examined. duration diabetes 8.4 +/- 0.8 years. BMI, glycosylated hemoglobin (HbA(1c)) levels, fasting concentrations plasma glucose, lipids (total cholesterol, high-density lipoprotein [HDL] triglycerides), measured. low-density (LDL) cholesterol level calculated using Friedewald formula (LDL = - HDL 1/5 triglycerides). Insulin estimated by homeostasis model assessment (HOMA-IR). Computed tomography (CT) used measure cross-sectional subcutaneous visceral areas all Adipose tissue determined at umbilical level. Subcutaneous 136.5 6.0 86.0 4.1 cm(2), respectively. Univariate regression analysis showed that positively correlated with (r =.544, P <.001) =.408, =.001) areas, BMI =.324, =.009), HbA(1c) =.254, =.001), triglycerides =.419, <.001), LDL =.290, =.019) levels negatively =.041). Multiple analyses independently predicted (F 6.76, 4.61, 8.88, level, which explained 36.9% variability resistance. Moreover, present demonstrated whereas =.510, =.553, triglyceride associated =.302, =.015), but not =.222, =.074) area. From these results, it can be suggested (1) both are (2) one, is our