Mechanisms of apoptosis induction by nucleoside analogs

摘要: Nucleoside analogs are structurally, metabolically, and pharmacodynamically related agents that nevertheless have diverse biological actions therapeutic consequences. This class of affects the structural integrity DNA, generally after incorporation during replication or DNA excision repair synthesis, leading to stalled forks chain termination. The damage sensors ATM, ATR DNA-PK recognize these events. These other protein kinases activate checkpoint pathways arrest cell cycle progression, also signal for repair. In addition, if survival mechanisms overwhelmed by caused, a third function is signaling initiate apoptotic processes. A review spectrum responses activated clinically relevant nucleoside begins provide mechanistic basis outcomes in viability. Such information, when coupled with an understanding intrinsic potential tumor type may rational design strategies.