Functionalized gold nanoparticle-polypyrrole nanobiocomposite with high effective surface area for electrochemical/pH dual stimuli-responsive smart release of insulin.
作者： Ehsan Shamaeli , Naader Alizadeh
DOI: 10.1016/J.COLSURFB.2015.01.003
关键词:
摘要: A novel functionalized gold nanoparticle-polypyrrole-nanobiocomposite (PPy-FGNP-NBC) with large effective surface area was fabricated for electrical/pH dual stimuli-responsive local delivery of insulin. The fabrication method involves simple electrodeposition and immobilization processes without use organic solvents. Release studies based on the nature insulin-surface binding indicated that release promoted PPy-FGNP-NBC. Kinetics analysis showed insulin strongly affected by applying external potential stimuli. Also, under influence pH slowed down lower pH. This pH-sensitivity remarkably increased potential. Based in vitro study applied condition, artificial gastric juice is significantly slower than intestinal fluid. Circular dichroism retained its original conformation during electrochemically stimulated release.
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