An association between homozygous C3 deficiency and low levels of anti-pneumococcal capsular polysaccharide antibodies.
作者： M. A. HAZLEWOOD , D. S. KUMARARATNE , A. D. B. WEBSTER , M. GOODALL , P. BIRD
DOI: 10.1111/J.1365-2249.1992.TB03010.X
关键词:
摘要: Inherited deficiencies of complement components are associated with an increased risk infection by encapsulated, high grade bacterial pathogens such as Streptococcus pneumoniae, Haemophilus influenzae type b and Neisseria meningitidis. Hence, the levels antibodies to capsular polysaccharide antigens were measured using ELISA in 65 patients inherited covering classical, alternative terminal cascade. Three four C3-deficient individuals studied found be almost totally deficient specific anti-pneumococcal (PCP) antibodies. These had a history recurrent pneumococcal sepsis. While single C1r, C2 C1Inh deficiency have low anti-PCP antibody levels, no other group significantly reduced compared 100 controls. Antibody two polysaccharides not lower patient groups. findings suggest that C3 may able provide stimulatory signal promote production
sci-hub.se 参考文章(41)
Schur Ph, IgG subclasses--a review. Annals of allergy. ,vol. 58, pp. 89- 100 ,(1987)
E. R. Moxon, J. S. Kroll, The Role of Bacterial Polysaccharide Capsules as Virulence Factors Current Topics in Microbiology and Immunology. ,vol. 150, pp. 65- 85 ,(1990) , 10.1007/978-3-642-74694-9_4
A. Segal, M. Walport, Neutrophil and Complement Defects: Recent Advances Springer Netherlands. pp. 149- 179 ,(1988) , 10.1007/978-94-009-1275-5_8
P G Shackelford, G A Weinberg, M H Nahm, D M Granoff, Functional activity of different IgG subclass antibodies against type b capsular polysaccharide of Haemophilus influenzae. Journal of Immunology. ,vol. 136, pp. 4232- 4236 ,(1986)
J H Humphrey, J Pryjma, Prolonged C3 depletion by cobra venom factor in thymus-deprived mice and its implication for the role of C3 as an essential second signal for B-cell triggering. Immunology. ,vol. 28, pp. 569- 576 ,(1975)
D Bitter-Suermann, T Hoffmann, U Hadding, S Metzger, E C Böttger, The role and mechanism of cobra venom factor-induced suppression of the humoral immune response in guinea pigs. Journal of Immunology. ,vol. 137, pp. 1280- 1285 ,(1986)
Henri A. Verbrugh, Wietse Kuis, Jan W. Stoop, John J. Roord, Mohamed Daha, Ben J. M. Zegers, Jan Verhoef, Inherited deficiency of the third component of complement associated with recurrent pyogenic infections, circulating immune complexes, and vasculitis in a Dutch family. Pediatrics. ,vol. 71, pp. 81- 87 ,(1983)
D AMBROSINO, D UMETSU, G SIBER, G HOWIE, T GOULARTE, R MICHAELS, P MARTIN, P SCHUR, J NOYES, G SCHIFFMAN, Selective defect in the antibody response to Haemophilus influenzae type b in children with recurrent infections and normal serum IgG subclass levels The Journal of Allergy and Clinical Immunology. ,vol. 81, pp. 1175- 1179 ,(1988) , 10.1016/0091-6749(88)90887-1
P. G. Shackelford, S. J. Nelson, Mitchell Scott, M. H. Nahm, D. S. Smith, D. M. Granoff, Subclass distribution of human antibodies to Haemophilus influenzae type b capsular polysaccharide. Journal of Immunology. ,vol. 138, pp. 587- 592 ,(1987)
Wim Timens, Sibrand Poppema, T Rozeboomuiterwijk, A Boes, Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response. Journal of Immunology. ,vol. 143, pp. 3200- 3206 ,(1989)