Menthol disrupts nicotine’s psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice
作者： Benjamin W. Fait , David C. Thompson , Tenna N. Mose , Peter Jatlow , Sven E. Jordt
DOI: 10.1016/J.BBR.2017.07.027
关键词:
摘要: Menthol is a commonly used flavorant in tobacco and e-cigarettes, could contribute to nicotine sensitivity. To understand how menthol intake addiction, it important determine whether specific mechanisms related sex age underlie behavioral changes induced by menthol-laced nicotinic products. Using validated paradigm of nicotine-dependent locomotor stimulation, adolescent adult C57BL/6J mice both sexes were exposed nicotine, or laced with menthol, as their sole source fluid, psychostimulant effects evaluated recording home cage activity for ten days. Nicotine cotinine blood levels measured following exposure. Results show an interaction between treatment, age, on liquid consumption, indicating that responded differently based sex. Adult male greatly increased when given menthol. In female groups, did not have this effect. Despite increase promoted showed significant decrease locomotion, suggesting blunted nicotine-induced psychostimulation. This response was detected either These data confirm more than flavorant, can influence its effects. results suggest age- sex-dependent menthol’s studies including smokers are warranted.
sci-hub.se 参考文章(34)
Eric Moolchan, Adolescent menthol smokers: will they be a harder target for cessation? Nicotine & Tobacco Research. ,vol. 6, pp. 93- 95 ,(2004) , 10.1080/14622203310001649522
Olivia Wackowski, Cristine D. Delnevo, Menthol cigarettes and indicators of tobacco dependence among adolescents. Addictive Behaviors. ,vol. 32, pp. 1964- 1969 ,(2007) , 10.1016/J.ADDBEH.2006.12.023
J. A. Sparks, J. R. Pauly, Effects of continuous oral nicotine administration on brain nicotinic receptors and responsiveness to nicotine in C57Bl/6 mice Psychopharmacology. ,vol. 141, pp. 145- 153 ,(1999) , 10.1007/S002130050818
Gary Giovino, Stephen Sidney, Joseph Gfroerer, Patrick O'Malley, Jane Allen, Patricia Richter, K Michael Cummings, Epidemiology of menthol cigarette use. Nicotine & Tobacco Research. ,vol. 6, pp. 67- 81 ,(2004) , 10.1080/14622203710001649696
Neal L. Benowitz, Brenda Herrera, Peyton Jacob, Mentholated Cigarette Smoking Inhibits Nicotine Metabolism Journal of Pharmacology and Experimental Therapeutics. ,vol. 310, pp. 1208- 1215 ,(2004) , 10.1124/JPET.104.066902
Abrar Ashoor, Jacob C. Nordman, Daniel Veltri, Keun-Hang Susan Yang, Lina Al Kury, Yaroslav Shuba, Mohamed Mahgoub, Frank C. Howarth, Bassem Sadek, Amarda Shehu, Nadine Kabbani, Murat Oz, Menthol Binding and Inhibition of α7-Nicotinic Acetylcholine Receptors PLoS ONE. ,vol. 8, pp. e67674- ,(2013) , 10.1371/JOURNAL.PONE.0067674
David T. Levy, Kenneth Blackman, John Tauras, Frank J. Chaloupka, Andrea C. Villanti, Raymond S. Niaura, Donna M. Vallone, David B. Abrams, Quit Attempts and Quit Rates Among Menthol and Nonmenthol Smokers in the United States American Journal of Public Health. ,vol. 101, pp. 1241- 1247 ,(2011) , 10.2105/AJPH.2011.300178
Mehmet Sofuoglu, Aryeh I Herman, Haleh Nadim, Peter Jatlow, Rapid nicotine clearance is associated with greater reward and heart rate increases from intravenous nicotine. Neuropsychopharmacology. ,vol. 37, pp. 1509- 1516 ,(2012) , 10.1038/NPP.2011.336
U. Maskos, B. E. Molles, S. Pons, M. Besson, B. P. Guiard, J.-P. Guilloux, A. Evrard, P. Cazala, A. Cormier, M. Mameli-Engvall, N. Dufour, I. Cloëz-Tayarani, A.-P. Bemelmans, J. Mallet, A. M. Gardier, V. David, P. Faure, S. Granon, J.-P. Changeux, Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature. ,vol. 436, pp. 103- 107 ,(2005) , 10.1038/NATURE03694
Stevens S. Smith, Michael C. Fiore, Timothy B. Baker, Smoking cessation in smokers who smoke menthol and non-menthol cigarettes Addiction. ,vol. 109, pp. 2107- 2117 ,(2014) , 10.1111/ADD.12661