Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer

摘要: Background Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients locally advanced laryngeal cancer. The value of adding and optimal timing are unknown. Methods We randomly assigned cancer larynx one three treatments: induction radiotherapy, concurrent administration cisplatin, or alone. primary end point was preservation larynx. Results A 547 were study groups. median follow-up period 3.8 years. At two years, proportion who had an intact after (88 percent) differed significantly from proportions in groups given (75 percent, P=0.005) alone (70 ...