Donor immunization with Haemophilus influenzae type b (HIB)-conjugate vaccine in allogeneic bone marrow transplantation

摘要: Bone marrow transplant patients are at increased risk for infections with polysaccharide encapsulated organisms and respond poorly to vaccines. We evaluated the effect of donor immunization Haemophilus influenzae type b (HIB) polysaccharide-conjugate vaccine on recipient antibody responses following allogeneic bone transplantation. Thirty-two their donors were immunized before transplantation HIB-conjugate, tetanus toxoid 23-valent pneumococcal Following transplantation, received HIB-conjugate vaccines 3, 6, 12, 24 months 12 months. Thirty-three unimmunized in an identical manner. Patients whose had significantly higher total anti-HIB concentrations 3 (P = .0001), 6 .002) after compared unimmunized. Higher antitetanus also noted donors, whereas no Donor resulted as early may be effective strategy prevent HIB infections.