Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations
作者： Thomas Lehrnbecher , Charles B. Foster , Shaoxian Zhu , Susan F. Leitman , Lynn R. Goldin
DOI: 10.1182/BLOOD.V94.12.4220
关键词:
摘要: Fcgamma-receptors (FcgammaR) provide a critical link between humoral and cellular immunity. The genes of the low-affinity receptors for IgG their isoforms, namely, FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa, FcgammaRIIIb, SH-FcgammaRIIIb, are located in close proximity on chromosome 1q22. Variant alleles may differ biologic activity number studies have reported frequencies variant FcgammaR both disease control populations. No large study has evaluated possibility nonrandom distribution genotypes. We analyzed 395 normal individuals (172 African Americans [AA] 223 Caucasians [CA]) at following loci: including SH-FcgammaRIIIb. genotypic distributions FcgammaRIIIb conform to Hardy-Weinberg law each group. There was no strong evidence that combinations 2-locus genotypes 3 loci deviated from random these healthy SH-FcgammaRIIIb is underrepresented CA compared with AA (P < .0001) controls. A previously FcgammaRIIb not detected 70 individuals, indicating this allele, if it exists, very rare (<1%). In conclusion, we present data should serve as foundation interpretation association involving multiple FcgammaR.
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