Rosette Trajectories Enable Ungated, Motion-Robust, Simultaneous Cardiac and Liver T 2 * Iron Assessment

作者: Adam M. Bush , Christopher M. Sandino , Shreya Ramachandran , Frank Ong , Nicholas Dwork

DOI: 10.1002/JMRI.27196

关键词:

摘要: BACKGROUND Quantitative T2 * MRI is the standard of care for assessment iron overload. However, patient motion corrupts estimates. PURPOSE To develop and evaluate a motion-robust, simultaneous cardiac liver imaging approach using non-Cartesian, rosette sampling model-based reconstruction as compared to clinical-standard Cartesian MRI. STUDY TYPE Prospective. PHANTOM/POPULATION Six ferumoxytol-containing phantoms (26-288 μg/mL). Eight healthy subjects 18 patients referred clinically indicated overload assessment. FIELD STRENGTH/SEQUENCE 1.5T, 2D gradient echo (GRE) ASSESSMENT: GRE values were validated in ferumoxytol phantoms. In subjects, test-retest spatial coefficient variation (CoV) analysis was performed during three breathing conditions. correlation Bland-Altman analysis. Images rated by experienced radiologists on 5-point scale. STATISTICAL TESTS Linear regression, variance (ANOVA), paired Student's t-testing used compare reproducibility variability metrics scans. The Wilcoxon rank test assess reader score comparisons reliability measured intraclass RESULTS Rosette R2* (1/T2 *) linearly correlated with concentration (r2 = 1.00) not significantly different than (P 0.16). During breath-holding, ungated heart had lower CoV (liver: 18.4 ± 9.3% Cartesian, 8.8% ± 3.4% rosette, P 0.02, heart: 37.7% ± 14.3% 13.4% ± 1.7% 0.001) higher-quality scores 3.3 [3.0-3.6] 4.7 [4.1-4.9] 0.005, 3.0 [2.3-3] 4.5 [3.8-5.0] 0.005) values. free-breathing failed images very poor average image quality significant artifacts, whereas remained good, minimal artifacts 0.001). DATA CONCLUSION k-sampling offers useful motion-robust mapping quantification. J. MAGN. RESON. IMAGING 2020;52:1688-1698.

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